| News & Updates | ALDH Overview | ALDH Gene Superfamily | ALDH Publications | Links | Contact Us | Vasiliou Laboratory |

ALDH Gene Record


Summary for ALDH7A1
Trivial Names & Synonyms
Database Accession ID's
Molecular Features
Polymorphisms
Substrates and Kinetic Values
Tissue Expression & Cellular Localization
Reference List

ALDH7A1

Summary for ALDH7A1:

ALDH7A1 encodes an ALDH also known as Antiquitin.

Human ALDH7A1 retains 60% homology to the green garden pea 26g protein involved in regulation of turgor pressure (8088832) . Due to the high degree of homology between proteins from the garden pea and the animal kingdom, it is assumed that the protein may have a significant indispensable physiological role in cell biology that related to the regulation of cellular turgor pressure. However, the exact physiological function of antiquitin remains to be determined.

Mammalian ALDH7A1 is thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation (11959129) .

Three pseudogenes of ALDH7A1 (ALDH7A1P1, ALDH7A1P2, and ALDH7A1P3) have been identified on separate chromosomes however the gene products have yet to be characterized.

 
 

Trivial Names and Synonyms for ALDH7A1:

Antiquitin 1,    ATQ1 (Atq1),    D18Wsu181e
 
 

Database Accession ID's for ALDH7A1:

Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Bos taurus
(Domestic cow)
Institute Database Accession No.
NCBIEntrez Gene507477
NCBIGenBankNC_007305
NCBIUniGene22086
Institute Database Accession No.
NCBIGenBankNM_001045969
Institute Database Accession No.
NCBIEntrez ProteinNP_001039434
EBI, SIB, PIRUniProtQ2KJC9
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Homo sapiens
(Human)
Institute Database Accession No.
NCBICCDS4137.1
NCBIEntrez Gene501
NCBIGenBankNC_000005
NCBIOMIM107323
NCBIUniGene483239
HUGOHGNC877
EBI, WTSIEnsembl - GeneViewENSG00000164904
Institute Database Accession No.
NCBIGenBankNM_001182
EBI, WTSIEnsembl - TransViewENST00000297542
Institute Database Accession No.
NCBIAceViewALDH7A1.aApr07, ALDH7A1.eApr07
NCBIEntrez ProteinNP_001173
EBI, WTSIEnsembl - ProtViewENSP00000297542
EBI, SIB, PIRUniProtP49419, Q6IPU8
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Mus musculus
(House mouse)
Institute Database Accession No.
NCBIEntrez Gene110695
NCBIGenBankNC_000084
NCBIUniGene30250
JLMGI108186
EBI, WTSIEnsembl - GeneViewENSMUSG00000053644
Institute Database Accession No.
NCBIGenBankNM_138600
EBI, WTSIEnsembl - TransViewENSMUST00000066208, ENSMUST00000116635
Institute Database Accession No.
NCBIEntrez ProteinNP_613066
EBI, WTSIEnsembl - ProtViewENSMUSP00000065089
EBI, WTSIEnsembl - TransViewENSMUSP00000112334
EBI, SIB, PIRUniProtQ9DBF1
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Rattus norvegicus
(Norway rat)
Institute Database Accession No.
NCBIEntrez Gene291450
NCBIGenBankNC_005117
NCBIUniGene7330
MCWRGD1308614
EBI, WTSIEnsembl - GeneViewENSRNOG00000014645
Institute Database Accession No.
NCBIGenBankXM_214535
EBI, WTSIEnsembl - TransViewENSRNOT00000020325
Institute Database Accession No.
NCBIEntrez ProteinXP_214535
EBI, WTSIEnsembl - ProtViewENSRNOP00000020325
EBI, SIB, PIRUniProtQ64057
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Vitis vinifera
(Wine Grape)
Institute Database Accession No.
NCBIGenBankNC_012017
Institute Database Accession No.
NCBIGenBankXM_002278057
Institute Database Accession No.
NCBIGenBankXP_002278093
 
 
 

Molecular Features for ALDH7A1:

Species  
Bos taurus
(Domestic cow)
Chromosome Locus : 7 (+ strand)
 
ALDH7A1_v?     (Alternative Splice Variant Unknown or To Be Determined) Number of Exons : N/A Click Here for Bos taurus Transcript Sequences for Unknown Variants
Click Here for Bos taurus Peptide Sequences for Unknown Variants
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
NM_001045969 4111 NP_001039434 539 58582 5.69 Click Here for Graphical and Tabular Details

Peptide : Isoform 1 of 1.

 
Species  
Homo sapiens
(Human)
Chromosome Locus : 5 q 31 (- strand)
 

 
ALDH7A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH7A1_v1 :   18 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 1
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000297542 1878 ENSP00000297542 539 58487 6.86 Click Here for Graphical and Tabular Details

NM_001182 1896 NP_001173 539 58487 6.44 Click Here for Graphical and Tabular Details

ALDH7A1.aApr07 3434 ALDH7A1.aApr07 539 58487 8.21 Click Here for Graphical and Tabular Details

 
 
ALDH7A1_v?     (Alternative Splice Variant Unknown or To Be Determined) Number of Exons : N/A Click Here for Homo sapiens Transcript Sequences for Unknown Variants
Click Here for Homo sapiens Peptide Sequences for Unknown Variants
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH7A1.eApr07 2041 ALDH7A1.eApr07 246 26691 7.01 Click Here for Graphical and Tabular Details

Transcript : The translation of this peptide begins with an alternative CTG initialization codon. Exon structure to be determined.

 
Species  
Mus musculus
(House mouse)
Chromosome Locus : 18 29.0 cM (- strand)
 

 
ALDH7A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH7A1_v1 :   18 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 1
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000066208 1824 ENSMUSP00000065089 511 55645 6.36 Click Here for Graphical and Tabular Details

NM_138600 2911 NP_613066 539 58862 7.16 Click Here for Graphical and Tabular Details

ENSMUST00000116635 1825 ENSMUSP00000112334 539 58862 7.52 Click Here for Graphical and Tabular Details

 
Species  
Rattus norvegicus
(Norway rat)
Chromosome Locus : 18 q 12.1 (- strand)
 

 
ALDH7A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH7A1_v1 :   18 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 1
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000020325 1893 ENSRNOP00000020325 539 58749 7.96 Click Here for Graphical and Tabular Details

XM_214535 1880 XP_214535 539 58749 7.99 Click Here for Graphical and Tabular Details

 
Species  
Vitis vinifera
(Wine Grape)
Chromosome Locus : 11 (- strand)
 

 
ALDH7A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH7A1_v1 :   14 Click Here for Vitis vinifera Transcript Sequences for Alternative Splice Variant 1
Click Here for Vitis vinifera Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
XM_002278057 1913 XP_002278093 508 54590 5.39 Click Here for Graphical and Tabular Details

 
 
 

Polymorphisms for ALDH7A1:

Currently Under Development
 
 

Substrates, Inhibitors and Enzyme Kinetics for ALDH7A1:

 
 

Tissue Expression & Cellular Localization for ALDH7A1:

Currently Under Development
 
 

Reference List for ALDH7A1:

ALDH7A1 Year Authors Title Journal Pubmed ID
2006 Fong, Cheng, Tang
Antiquitin, a relatively unexplored member in the superfamily of aldehyde dehydrogenases with diversified physiological functions. Cell Mol Life Sci 17131062
 
2002 Tang, Cheng, Fong
First purification of the antiquitin protein and demonstration of its enzymatic activity. FEBS Lett 11959129
 
1994 Lee, Kuhl, Gelbart, Kamimura, West, Beutler
Homology between a human protein and a protein of the green garden pea. Genomics 8088832
 
 
 

Copyright © 2002 - 2013, The Gene Superfamily Resource Centers