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ALDH1A3

ALDH Gene Record


Summary for ALDH1A3
Trivial Names & Synonyms
Database Accession ID's
Molecular Features
Polymorphisms
Substrates and Kinetic Values
Tissue Expression & Cellular Localization
Reference List

ALDH1A3

Summary for ALDH1A3:

ALDH1A3 is a cytosolic homotetramer (~56 kDa subunits) and is expressed in an organ- and tissue specific manner at low levels in most organs but at higher levels in the salivary gland, stomach and kidney (7698756) . ALDH1A3 is often referred to as the third retinaldehyde dehydrogenase, RALDH3. Like ALDH1A2, it is differentially activated during early embryonic head and forebrain development. Studies using ALDH1A3 knockout mice demonstrated perinatal lethality due to nasal defects that occurred during embryonic development (14623956) .

 
 

Trivial Names and Synonyms for ALDH1A3:

Aldehyde dehydrogenase 6,    ALDH1A6,    ALDH6,    RALDH3,    RALDH3 (Raldh3),    Retinaldehyde dehydrogenase 3,    V1
 
 

Database Accession ID's for ALDH1A3:

Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Bos taurus
(Domestic cow)
Institute Database Accession No.
NCBIEntrez Gene507093
NCBIGenBankNC_007319
NCBIUniGene62499
Institute Database Accession No.
NCBIGenBankXM_583647
Institute Database Accession No.
NCBIEntrez ProteinXP_583647
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Homo sapiens
(Human)
Institute Database Accession No.
NCBICCDS10389.1
NCBIEntrez Gene220
NCBIGenBankNC_000015
NCBIOMIM600463
NCBIUniGene459538
HUGOHGNC409
EBI, WTSIEnsembl - GeneViewENSG00000184254
Institute Database Accession No.
NCBIGenBankNM_000693
EBI, WTSIEnsembl - TransViewENST00000346623, ENST00000329841
Institute Database Accession No.
NCBIAceViewALDH1A3.aApr07, ALDH1A3.bApr07, ALDH1A3.eApr07
NCBIEntrez ProteinNP_000684
EBI, WTSIEnsembl - ProtViewENSP00000343294, ENSP00000332256
EBI, SIB, PIRUniProtP47895
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Mus musculus
(House mouse)
Institute Database Accession No.
NCBIEntrez Gene56847
NCBIGenBankNC_000073
NCBIUniGene140988
JLMGI1861722
EBI, WTSIEnsembl - GeneViewENSMUSG00000015134
Institute Database Accession No.
NCBIGenBankNM_053080
EBI, WTSIEnsembl - TransViewENSMUST00000015278
Institute Database Accession No.
NCBIEntrez ProteinNP_444310
EBI, WTSIEnsembl - ProtViewENSMUSP00000082294, ENSMUSP00000015278
EBI, SIB, PIRUniProtQ9JHW9
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Rattus norvegicus
(Norway rat)
Institute Database Accession No.
NCBIEntrez Gene266603
NCBIGenBankNC_005100
NCBIUniGene162434
MCWRGD628662
EBI, WTSIEnsembl - GeneViewENSRNOG00000013028
Institute Database Accession No.
NCBIGenBankNM_153300
EBI, WTSIEnsembl - TransViewENSRNOT00000047456, ENSRNOT00000043019, ENSRNOT00000017506
Institute Database Accession No.
NCBIEntrez ProteinNP_695212
EBI, WTSIEnsembl - ProtViewENSRNOP00000050331, ENSRNOP00000045261, ENSRNOP00000017506
EBI, SIB, PIRUniProtQ8K4D8
 
 
 

Molecular Features for ALDH1A3:

Species  
Bos taurus
(Domestic cow)
Chromosome Locus : 21 (- strand)
 

 
ALDH1A3_v1     (Alternative Splice Variant 1) Number of Exons for ALDH1A3_v1 :   13 Click Here for Bos taurus Transcript Sequences for Alternative Splice Variant 1
Click Here for Bos taurus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
XM_583647 3427 XP_583647 537 59119 5.30 Click Here for Graphical and Tabular Details

 
Species  
Homo sapiens
(Human)
Chromosome Locus : 15 q 26.3 (+ strand)
 

 
ALDH1A3_v1     (Alternative Splice Variant 1) Number of Exons for ALDH1A3_v1 :   13 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 1
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000329841 3443 ENSP00000332256 512 56109 7.29 Click Here for Graphical and Tabular Details

NM_000693 3510 NP_000684 512 56109 6.64 Click Here for Graphical and Tabular Details

Peptide : Residue 15 of this protein ALDH.ORG is translated to "R" (arginine). Residue 15 of this protein for NP_000684 in GenPept is translated to "G" (glycine). Requires review. (2008-06-07 WJB)

ALDH1A3.aApr07 3931 ALDH1A3.aApr07 512 56109 6.99 Click Here for Graphical and Tabular Details

 
 
ALDH1A3_v2     (Alternative Splice Variant 2) Number of Exons for ALDH1A3_v2 :   10 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 2
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000346623 3122 ENSP00000343294 405 44257 8.45 Click Here for Graphical and Tabular Details

ALDH1A3.bApr07 3106 ALDH1A3.bApr07 405 44257 8.45 Click Here for Graphical and Tabular Details

 
 
ALDH1A3_v3     (Alternative Splice Variant 3) Number of Exons for ALDH1A3_v3 :   5 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 3
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 3
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH1A3.eApr07 4162 ALDH1A3.eApr07 178 18838 9.89 Click Here for Graphical and Tabular Details

Transcript : This peptide translation does not encode ALDH1A3 and should not be considered an ALDH1A3 peptide. The transcript is within the human ALDH1A3 gene region but does not code for ALDH1A3. Searching PFAM database with the peptide sequence translation of this transcript demonstrates no aldehyde dehydrogenase protein domain within the sequence.

 
Species  
Mus musculus
(House mouse)
Chromosome Locus : 7 C (- strand)
 

 
ALDH1A3_v1     (Alternative Splice Variant 1) Number of Exons for ALDH1A3_v1 :   13 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 1
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000015278 3398 ENSMUSP00000015278 512 56158 6.52 Click Here for Graphical and Tabular Details

NM_053080 3423 NP_444310 512 56158 6.19 Click Here for Graphical and Tabular Details

 
Species  
Rattus norvegicus
(Norway rat)
Chromosome Locus : 1 q 22 (- strand)
 

 
ALDH1A3_v1     (Alternative Splice Variant 1) Number of Exons for ALDH1A3_v1 :   15 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 1
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000047456 1539 ENSRNOP00000050331 512 56284 7.13 Click Here for Graphical and Tabular Details

 
 
ALDH1A3_v2     (Alternative Splice Variant 2) Number of Exons for ALDH1A3_v2 :   15 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 2
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000043019 1545 ENSRNOP00000045261 514 56320 5.99 Click Here for Graphical and Tabular Details

 
 
ALDH1A3_v3     (Alternative Splice Variant 3) Number of Exons for ALDH1A3_v3 :   5 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 3
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 3
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000017506 696 ENSRNOP00000017506 176 18991 6.88 Click Here for Graphical and Tabular Details

Peptide : This is product of an incomplete transcript sequence - an initialization codon (ATG) is not present on the 5 prime end of transcript sequence. ALDH.ORG uses the first ATG codon. The transcript sequence also exhibits a 5 base deletion in the last exon which is within the coding region.

Deletions : 5 base deletion(s) identified

 
 
ALDH1A3_v4     (Alternative Splice Variant 4) Number of Exons for ALDH1A3_v4 :   13 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 4
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 4
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
NM_153300 1539 NP_695212 512 56172 Click Here for Graphical and Tabular Details

Transcript : The transcript sequence failed to align to the genomic sequence (NC_005100) surrounding Exon 10 and 11. The SAST algorithm was unable to appropriately align this sequence area. Manual alignment was required due to significant genomic anomalies as a result of an incomplete genomic sequence at the 5-prime end of Exon 11 (the first 88 bases of this exon are incomplete in the genomic assembly and are represented as N.

SNP's : 88 single nucleotide polymorphism(s) identified

 
 
 

Polymorphisms for ALDH1A3:

Currently Under Development
 
 

Substrates, Inhibitors and Enzyme Kinetics for ALDH1A3:

 
 

Tissue Expression & Cellular Localization for ALDH1A3:

Currently Under Development
 
 

Reference List for ALDH1A3:

ALDH1A3 Year Authors Title Journal Pubmed ID
2007 Trasino, Harrison, Wang
Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP. Exp Biol Med (Maywood) 17526768
 
2003 Dupé, Matt, Garnier, Chambon, Mark, Ghyselinck
A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc Natl Acad Sci U S A 14623956
 
2002 Niederreither, Fraulob, Garnier, Chambon, Dollé
Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse. Mech Dev 11744377
 
2001 Pappas, Stephanou, Karamanakos, Vasiliou, Marselos
Phenobarbital inducibility and differences in protein expression of an animal model Chem Biol Interact 11306051
 
2000 Duester
Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur J Biochem 10880953
 
1999 Niederreither, Subbarayan, Dollé, Chambon
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet 10192400
 
1994 Hsu, Chang, Hiraoka, Hsieh
Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6. Genomics 7698756
 
 
 

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