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ALDH1B1

ALDH Gene Record


Summary for ALDH1B1
Trivial Names & Synonyms
Database Accession ID's
Molecular Features
Polymorphisms
Substrates and Kinetic Values
Tissue Expression & Cellular Localization
Reference List

ALDH1B1

Summary for ALDH1B1:

ALDH1B1 is an NAD+-dependent mitochondrial homotetramer (~57.3 kDa subunits) expressed in the liver and testis (2061311) as well as kidney, skeletal muscle and fetal tissues (7779080) . ALDH1B1 may also be expressed in the cornea although further investigation is required as only a partial sequence of the enzyme has been identified (8493893) . ALDH1B1 is unique from other ALDHs by virtue being encoded by an intron-less gene. This enzyme has ~72% sequence homology to ALDH2 and is insensitive to inhibition by disulfiram.

 
 

Trivial Names and Synonyms for ALDH1B1:

2700007F14Rik,    ALDH5,    ALDHx,    MGC101971
 
 

Database Accession ID's for ALDH1B1:

Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Homo sapiens
(Human)
Institute Database Accession No.
NCBICCDS6615.1
NCBIEntrez Gene219
NCBIGenBankNC_000009
NCBIOMIM100670
NCBIUniGene436219
HUGOHGNC407
EBI, WTSIEnsembl - GeneViewENSG00000137124
Institute Database Accession No.
NCBIGenBankNM_000692
EBI, WTSIEnsembl - TransViewENST00000259658, ENST00000377698
Institute Database Accession No.
NCBIAceViewALDH1B1.bApr07
NCBIEntrez ProteinNP_000683
EBI, WTSIEnsembl - ProtViewENSP00000366927, ENSP00000259658
EBI, SIB, PIRUniProtP30837, Q9BV45
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Mus musculus
(House mouse)
Institute Database Accession No.
NCBIEntrez Gene72535
NCBIGenBankNC_000070
NCBIUniGene331583
JLMGI1919785
EBI, WTSIEnsembl - GeneViewENSMUSG00000035561
Institute Database Accession No.
NCBIGenBankNM_028270
EBI, WTSIEnsembl - TransViewENSMUST00000044384
Institute Database Accession No.
NCBIEntrez ProteinNP_082546
EBI, WTSIEnsembl - ProtViewENSMUSP00000041260
EBI, SIB, PIRUniProtQ9CZS1, Q3UAH5
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Rattus norvegicus
(Norway rat)
Institute Database Accession No.
NCBIEntrez Gene298079
NCBIGenBankNC_005104
NCBIUniGene12547
MCWRGD1306737
EBI, WTSIEnsembl - GeneViewENSRNOG00000011497
Institute Database Accession No.
NCBIGenBankNM_001011975
EBI, WTSIEnsembl - TransViewENSRNOT00000015281
Institute Database Accession No.
NCBIEntrez ProteinNP_001011975
EBI, WTSIEnsembl - ProtViewENSRNOP00000015282
EBI, SIB, PIRUniProtQ66HF8
 
 
 

Molecular Features for ALDH1B1:

Species  
Homo sapiens
(Human)
Chromosome Locus : 9 p 11.1 (+ strand)
 

 
ALDH1B1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH1B1_v1 :   2 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 1
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
NM_000692 3044 NP_000683 517 57250 6.99 Click Here for Graphical and Tabular Details

ENST00000377698 3022 ENSP00000366927 517 57250 6.99 Click Here for Graphical and Tabular Details

ALDH1B1.bApr07 3083 ALDH1B1.bApr07 517 57250 6.54 Click Here for Graphical and Tabular Details

 
Species  
Mus musculus
(House mouse)
Chromosome Locus : 4 2 B (+ strand)
 

 
ALDH1B1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH1B1_v1 :   2 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 1
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000044384 2196 ENSMUSP00000041260 519 57553 7.02 Click Here for Graphical and Tabular Details

NM_028270 2302 NP_082546 519 57553 6.59 Click Here for Graphical and Tabular Details

 
Species  
Rattus norvegicus
(Norway rat)
Chromosome Locus : 1 q 22 (+ strand)
 

 
ALDH1B1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH1B1_v1 :   2 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 1
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000015281 2197 ENSRNOP00000015282 519 57659 6.62 Click Here for Graphical and Tabular Details

NM_001011975 2221 NP_001011975 519 57625 6.62 Click Here for Graphical and Tabular Details

SNP's : 1 single nucleotide polymorphism(s) identified

 
 
 

Polymorphisms for ALDH1B1:

Currently Under Development
 
 

Substrates, Inhibitors and Enzyme Kinetics for ALDH1B1:

 
 

Tissue Expression & Cellular Localization for ALDH1B1:

Currently Under Development
 
 

Reference List for ALDH1B1:

ALDH1B1 Year Authors Title Journal Pubmed ID
1996 Stewart, Malek, Crabb
Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 8689400
 
1995 Stewart, Malek, Xiao, Dipple, Crabb
The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. Biochem Biophys Res Commun 7779080
 
1993 Algar, Cheung, Hayes, Holmes, Beacham
Bovine corneal aldehyde dehydrogenases: evidence for multiple gene products (ALDH3 and ALDHX). Adv Exp Med Biol 8493893
 
1991 Hsu, Chang
Cloning and characterization of a new functional human aldehyde dehydrogenase gene. J Biol Chem 2061311
 
 
 

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