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ALDH3A1

ALDH Gene Record


Summary for ALDH3A1
Trivial Names & Synonyms
Database Accession ID's
Molecular Features
Polymorphisms
Substrates and Kinetic Values
Tissue Expression & Cellular Localization
Reference List

ALDH3A1

Summary for ALDH3A1:

ALDH3A1 is a cytosolic homodimer (~50.4 kDa subunits) (4073832) constitutively expressed at considerably high levels (10-40% of the water-soluble protein) in the cornea of several mammalian species including humans (9723161) , (2802624) , (10376761) , (8617795) .

ALDH3A1 may have been recruited by gene sharing as major corneal proteins, called crystallins, which serve as structural elements in the eye (9599288) .

The specific roles of ALDH3A1 are a matter of current investigations and may include maintenance of corneal transparency, protection of lens crystallins by hydroxyl radical (•OH) scavenging (8670773) , direct absorption of UV-light (2209753) , generation of NAD(P)H for glutathione reduction and UVB absorption, and metabolism of cytotoxic aldehydes generated from UV-induced lipid peroxidation (12706498) , (12943535) , (8260946) .

Further investigations have implicated ALDH3A1 as a negative cell cycle regulator elongating the cell cycle and altering checkpoint protein expression levels (15905174) .

The protective role of ALDH3A1 in the cornea is apparent by studies in SWR/J mice that exhibit limited functionality of this enzyme (8500338) , (8131409) due to four amino acid substitutions (G88R, I154N, H305R and I352V) leading to complete loss of the ALDH3A1 catalytic activity (10376761) . These mice display significant sensitivities to UV-induced corneal clouding compared to wild type mice expressing ALDH3A1 (10376761) , (9192162) .

The rabbit is the only mammalian species examined thus far that lacks ALDH3A1 expression in the cornea. This lack of expression is believed to be compensated for by elevated levels of ALDH1A1 (12604188) .

ALDH3A1 and ALDH3A2 are primarily involved in the oxidation of medium- and long-chain aliphatic and aromatic aldehydes. Both of these genes are also dioxin-inducible.

 
 

Trivial Names and Synonyms for ALDH3A1:

acetaldehyde dehydrogenase,    Ahd-c,    Ahd4 (Ahd-4),    AHDC,    aldehyde dehydrogenase, dimeric NADP-preferring,    ALDH, stomach type,    ALDH3 (Aldh3)
 
 

Database Accession ID's for ALDH3A1:

Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Homo sapiens
(Human)
Institute Database Accession No.
NCBICCDS11212.1
NCBIEntrez Gene218
NCBIGenBankNC_000017
NCBIOMIM100660
NCBIUniGene531682
HUGOHGNC405
EBI, WTSIEnsembl - GeneViewENSG00000108602
Institute Database Accession No.
NCBIGenBankNM_000691
EBI, WTSIEnsembl - TransViewENST00000333946, ENST00000225740, ENST00000379258, ENST00000395555
Institute Database Accession No.
NCBIAceViewALDH3A1.aApr07, ALDH3A1.dApr07, ALDH3A1.hApr07, ALDH3A1.cApr07, ALDH3A1.eApr07
NCBIEntrez ProteinNP_000682
EBI, WTSIEnsembl - ProtViewENSP00000334590, ENSP00000225740, ENSP00000368560
EBI, WTSIEnsembl - TransViewENSP00000378923
EBI, SIB, PIRUniProtP30838
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Mus musculus
(House mouse)
Institute Database Accession No.
NCBIEntrez Gene11670
NCBIGenBankNC_000077
NCBIUniGene4257
JLMGI1353451
EBI, WTSIEnsembl - GeneViewENSMUSG00000019102
Institute Database Accession No.
NCBIGenBankNM_007436
EBI, WTSIEnsembl - TransViewENSMUST00000019246, ENSMUST00000108716
Institute Database Accession No.
NCBIEntrez ProteinNP_031462
EBI, WTSIEnsembl - ProtViewENSMUSP00000019246
EBI, WTSIEnsembl - TransViewENSMUSP00000104356
EBI, SIB, PIRUniProtQ5SU79, Q9R203, P47739, Q5SU80
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Rattus norvegicus
(Norway rat)
Institute Database Accession No.
NCBIEntrez Gene25375
NCBIGenBankNC_005109
NCBIUniGene105627
MCWRGD2088
EBI, WTSIEnsembl - GeneViewENSRNOG00000002331
Institute Database Accession No.
NCBIGenBankNM_031972
EBI, WTSIEnsembl - TransViewENSRNOT00000003182
Institute Database Accession No.
NCBIEntrez ProteinNP_114178
EBI, WTSIEnsembl - ProtViewENSRNOP00000003182
EBI, SIB, PIRUniProtP11883
 
 
 

Molecular Features for ALDH3A1:

Species  
Homo sapiens
(Human)
Chromosome Locus : 17 p 11.2 (- strand)
 

 
ALDH3A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH3A1_v1 :   11 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 1
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000225740 1773 ENSP00000225740 453 50395 6.52 Click Here for Graphical and Tabular Details

ENST00000379258 1769 ENSP00000368560 380 41858 Click Here for Graphical and Tabular Details

Transcript : Incomplete/truncated transcript sequence. Ensembl Transview's translation lacks an initialization codon (ATG). ALDH.ORG translation is in the same reading frame but begins downstream of the Ensembl translation.

Peptide : Incomplete transcript sequence. Ensembl translation lacks initialization codon. ALDH.ORG translation begins in the same reading frame but downstream of the Ensembl translation

Deletions : 4 base deletion(s) identified

NM_000691 1722 NP_000682 453 50395 6.11 Click Here for Graphical and Tabular Details

ALDH3A1.cApr07 1779 ALDH3A1.cApr07 453 50395 6.11 Click Here for Graphical and Tabular Details

 
 
ALDH3A1_v2     (Alternative Splice Variant 2) Number of Exons for ALDH3A1_v2 :   9 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 2
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH3A1.aApr07 2140 ALDH3A1.aApr07 570 61575 8.97 Click Here for Graphical and Tabular Details

 
 
ALDH3A1_v3     (Alternative Splice Variant 3) Number of Exons for ALDH3A1_v3 :   11 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 3
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 3
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH3A1.dApr07 1658 ALDH3A1.dApr07 452 50266 6.24 Click Here for Graphical and Tabular Details

 
 
ALDH3A1_v4     (Alternative Splice Variant 4) Number of Exons for ALDH3A1_v4 :   9 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 4
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 4
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH3A1.hApr07 1351 ALDH3A1.hApr07 323 35666 5.53 Click Here for Graphical and Tabular Details

 
 
ALDH3A1_v5     (Alternative Splice Variant 5) Number of Exons for ALDH3A1_v5 :   8 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 5
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 5
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000333946 1944 ENSP00000334590 570 61575 8.74 Click Here for Graphical and Tabular Details

 
 
ALDH3A1_v6     (Alternative Splice Variant 6) Number of Exons for ALDH3A1_v6 :   10 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 6
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 6
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000395555 1495 ENSP00000378923 389 43307 6.60 Click Here for Graphical and Tabular Details

 
 
ALDH3A1_v7     (Alternative Splice Variant 7) Number of Exons for ALDH3A1_v7 :   10 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 7
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 7
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH3A1.eApr07 1567 ALDH3A1.eApr07 380 41858 Click Here for Graphical and Tabular Details

Transcript : The ACEVIEW translation lacks an initialization codon possible due to a truncated 5'transcript sequence. ALDH.ORG begins the translation downstream and in the same reading frame.

 
Species  
Mus musculus
(House mouse)
Chromosome Locus : 11 34.25 cM (+ strand)
 

 
ALDH3A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH3A1_v1 :   11 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 1
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000019246 1722 ENSMUSP00000019246 453 50481 6.95 Click Here for Graphical and Tabular Details

NM_007436 1729 NP_031462 453 50481 Click Here for Graphical and Tabular Details

 
 
ALDH3A1_v2     (Alternative Splice Variant 2) Number of Exons for ALDH3A1_v2 :   11 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 2
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000108716 1721 ENSMUSP00000104356 453 50481 6.95 Click Here for Graphical and Tabular Details

 
Species  
Rattus norvegicus
(Norway rat)
Chromosome Locus : 10 q 22 (+ strand)
 

 
ALDH3A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH3A1_v1 :   11 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 1
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000003182 1748 ENSRNOP00000003182 453 50339 6.79 Click Here for Graphical and Tabular Details

NM_031972 1725 NP_114178 453 50339 6.33 Click Here for Graphical and Tabular Details

Transcript : Transcript sequence does not align with genomic DNA. Further analysis for exon structure and sequence integrity required.

SNP's : 8 single nucleotide polymorphism(s) identified

Insertions : 3 base insertion(s) identified

 
 
 

Polymorphisms for ALDH3A1:

Currently Under Development
 
 

Substrates, Inhibitors and Enzyme Kinetics for ALDH3A1:

Species  
Bos taurus
(Domestic cow)
Substrate [Substrate] Experimental Design Activity Km Vmax Kcat ALDG.ORG Curator Comments Pubmed ID
4-hydroxy-2-nonenal
System :Purified Protein
 
Tissue Type :Cornea
 
400 μM 2209753
acetaldehyde
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
11.72 mM 24 1483503
benzaldehyde
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
[Cofactor] : 2.5 mM
 
0.26 mM 399 % 1483503
Inhibitor : Disulfuram
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
[Cofactor] : 2.5 mM
 
Insensitive to inhibition for both NAD+-dependent proprionaldehyde and NADP+-dependent benzaldehyde metabolism 1483503
Inhibitor : p-Hydroxymercuribenzoate
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
[Cofactor] : 2.5 mM
 
Did not inhibit NAD+-dependent proprionaldehyde activity but completely inhibited NADP+-dependent benzaldehyde metabolism 1483503
phenylacetaldehyde
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
[Cofactor] : 2.5 mM
 
N.D. 19 % 1483503
proprionaldehyde
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
[Cofactor] : 2.5 mM
 
7.0 mM 100 % 1483503
  
Species  
Papio hamadryas
(Baboon)
Substrate [Substrate] Experimental Design Activity Km Vmax Kcat ALDG.ORG Curator Comments Pubmed ID
4-hydroxy-2-nonenal
Tissue Type :Cornea
 
220 μM 2053490
  
Species  
Homo sapiens
(Human)
Substrate [Substrate] Experimental Design Activity Km Vmax Kcat ALDG.ORG Curator Comments Pubmed ID
4-hydroxy-2-nonenal 0-1000 μM
System :In Vitro - ALDH3A1 Activity in Cell Extracts
 
Tissue Type :Cornea
 
Cell Type : Epithelium
 
Cell Line : SV40-transformed Human Corneal Epithelial Cell Line (HCE)- Transfected with Human ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
54 μM 12706498
4-hydroxy-2-nonenal 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
45 ± 18 μM 963 ± 140
(nmol NADPH/min/mg protein)
12943535
6-phosphogluconate 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
0 0 12943535
6-phosphoglucono-δ-lactone 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
0 0 12943535
acetaldehyde 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
7034 ± 635 μM 5445 ± 133
(nmol NADPH/min/mg protein)
12943535
acetaldehyde
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
67 mM 36 9723161
benzaldehyde 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
200 ± 30 μM 19574 ± 724
(nmol NADPH/min/mg protein)
12943535
decanal 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
0.8 ± 0.2 μM 535 ± 26
(nmol NADPH/min/mg protein)
12943535
dodecanal 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
0.5 ± 0.1 μM 500 ± 28
(nmol NADPH/min/mg protein)
12943535
glucose-6-phosphate 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
0 0 12943535
glyceraldehyde 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
10500 ± 3769 μM 87 ± 17.4
(nmol NADPH/min/mg protein)
12943535
hexanal 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
18 ± 1.6 μM 2570 ± 59
(nmol NADPH/min/mg protein)
12943535
Inhibitor : Disulfuram
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
Insensitive to 50 μM 9723161
malondialdehyde 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
6550 ± 501 μM 685 ± 31
(nmol NADPH/min/mg protein)
12943535
malondialdehyde
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
0.0 0 9723161
nonanal 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
0.5 ± 0.2 μM 734 ± 44
(nmol NADPH/min/mg protein)
12943535
octanal 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
1 ± 1.2 μM 251 ± 11
(nmol NADPH/min/mg protein)
12943535
proprionaldehyde 1/10 apparent Km to 10X apparent Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
4736 ± 400 μM 426 ± 24.3
(nmol NADPH/min/mg protein)
12943535
trans-2-hexanal 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
155 ± 26 μM 1676 ± 67
(nmol NADPH/min/mg protein)
12943535
trans-2-hexanal
System :Purified Protein
 
Tissue Type :Cornea
 
Cofactor : NAD+
 
0.1 mM 53 9723161
trans-2-nonenal 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
12 ± 3 μM 5150 ± 261
(nmol NADPH/min/mg protein)
12943535
trans-2-octanal 1/10 apparent Km to 10X Km
System :Purified Recombinant ALDH3A1
 
Cofactor : NADP+
 
[Cofactor] : 2.5 mM
 
35 ± 7 μM 7303 ± 482
(nmol NADPH/min/mg protein)
12943535
  
 
 

Tissue Expression & Cellular Localization for ALDH3A1:

Currently Under Development
 
 

Reference List for ALDH3A1:

ALDH3A1 Year Authors Title Journal Pubmed ID
2008 Lassen, Black, Estey, Vasiliou
The role of corneal crystallins in the cellular defense mechanisms against oxidative stress. Semin Cell Dev Biol 18077195
 
2007 Lassen, Bateman, Estey, Kuszak, Nees, Piatigorsky, Duester, Day, Huang, Hines, Vasiliou
Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in aldh3a1(-/-)/aldh1a1(-/-) knockout mice. J Biol Chem 17567582
 
2007 Estey, Cantore, Weston, Carpenter, Petrash, Vasiliou
Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1 J Biol Chem 17158879
 
2007 Estey, Piatigorsky, Lassen, Vasiliou
ALDH3A1: a corneal crystallin with diverse functions Exp Eye Res 16797007
 
2006 Lassen, Pappa, Black, Jester, Day, Min, Min, Vasiliou
Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts Free Radic Biol Med 17023273
 
2006 Muzio, Trombetta, Maggiora, Martinasso, Vasiliou, Lassen, Canuto
Arachidonic acid suppresses growth of human lung tumor A549 cells through down-regulation of ALDH3A1 expression Free Radic Biol Med 16716894
 
2005 Pappa, Brown, Koutalos, DeGregori, White, Vasiliou
Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells J Biol Chem 15905174
 
2003 Pappa, Estey, Manzer, Brown, Vasiliou
Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in the cornea Biochem J 12943535
 
2003 Pappa, Chen, Koutalos, Townsend, Vasiliou
Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage Free Radic Biol Med 12706498
 
2003 Sládek
Transient induction of increased aldehyde dehydrogenase 3A1 levels in cultured human breast (adeno)carcinoma cell lines via 5'-upstream xenobiotic, and electrophile, responsive elements is, respectively, estrogen receptor-dependent and -independent Chem Biol Interact 12604190
 
2003 Manzer, Pappa, Estey, Sládek, Carpenter, Vasiliou
Ultraviolet radiation decreases expression and induces aggregation of corneal ALDH3A1 Chem Biol Interact 12604188
 
2002 Sládek, Kollander, Sreerama, Kiang
Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens Cancer Chemother Pharmacol 11914911
 
2001 Sládek, Rekha, Lee, Nagasawa
Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues Chem Biol Interact 11672702
 
2001 Sreerama, Sládek
Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes Chem Biol Interact 11306049
 
2001 Pappa, Sophos, Vasiliou
Corneal and stomach expression of aldehyde dehydrogenases: from fish to mammals Chem Biol Interact 11306042
 
1999 Vasiliou, Reuter, Williams, Puga, Nebert
Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression Pharmacogenetics 10591537
 
1999 Shiao, Tran, Siegel, Lee, Vasiliou
Four amino acid changes are associated with the Aldh3a1 locus polymorphism in mice which may be responsible for corneal sensitivity to ultraviolet light Pharmacogenetics 10376761
 
1999 Vasiliou, Shiao
The lack of AHD4 induction by TCDD in corneal cells may involve tissue-specific regulatory proteins Adv Exp Med Biol 10352684
 
1999 Stephanou, Pappas, Vasiliou, Marselos
Prepubertal regulation of the rat dioxin-inducible aldehyde dehydrogenase (ALDH3) Adv Exp Med Biol 10352679
 
1998 King, Holmes
Human ocular aldehyde dehydrogenase isozymes: distribution and properties as major soluble proteins in cornea and lens. J Exp Zool 9723161
 
1998 Piatigorsky
Multifunctional lens crystallins and corneal enzymes. More than meets the eye. Ann N Y Acad Sci 9599288
 
1997 Downes, Swann, Holmes
A genetic basis for corneal sensitivity to ultraviolet light among recombinant SWXJ inbred strains of mice. Curr Eye Res 9192162
 
1996 Uma, Hariharan, Sharma, Balasubramanian
Effect of UVB radiation on corneal aldehyde dehydrogenase. Curr Eye Res 8670773
 
1996 Boesch, Lee, Lindahl
Constitutive expression of class 3 aldehyde dehydrogenase in cultured rat corneal epithelium. J Biol Chem 8617795
 
1995 Agarwal, von Eitzen, Meier-Tackmann, Goedde
Metabolism of cyclophosphamide by aldehyde dehydrogenases. Adv Exp Med Biol 7484368
 
1994 Downes, Swann, Holmes
Differential corneal sensitivity to ultraviolet light among inbred strains of mice. Correlation of ultraviolet B sensitivity with aldehyde dehydrogenase deficiency. Cornea 8131409
 
1994 von Eitzen, Meier-Tackmann, Agarwal, Goedde
Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes. Cancer Lett 8124665
 
1993 Downes, Swann, Holmes
Ultraviolet light-induced pathology in the eye: associated changes in ocular aldehyde dehydrogenase and alcohol dehydrogenase activities. Cornea 8500338
 
1993 Algar, Cheung, Hayes, Holmes, Beacham
Bovine corneal aldehyde dehydrogenases: evidence for multiple gene products (ALDH3 and ALDHX). Adv Exp Med Biol 8493893
 
1993 King, Holmes
Human corneal aldehyde dehydrogenase: purification, kinetic characterisation and phenotypic variation. Biochem Mol Biol Int 8260946
 
1992 Konishi, Mimura
Kinetic properties of the bovine corneal aldehyde dehydrogenase (BCP 54). Exp Eye Res 1483503
 
1991 Algar, Abedinia, VandeBerg, Holmes
Purification and properties of baboon corneal aldehyde dehydrogenase: proposed UVR protective role. Adv Exp Med Biol 2053490
 
1990 Abedinia, Pain, Algar, Holmes
Bovine corneal aldehyde dehydrogenase: the major soluble corneal protein with a possible dual protective role for the eye. Exp Eye Res 2209753
 
1989 Evces, Lindahl
Characterization of rat cornea aldehyde dehydrogenase. Arch Biochem Biophys 2802624
 
1985 Santisteban, Povey, West, Parrington, Hopkinson
Chromosome assignment, biochemical and immunological studies on a human aldehyde dehydrogenase, ALDH3. Ann Hum Genet 4073832
 
 
 

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