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ALDH3A2

ALDH Gene Record


Summary for ALDH3A2
Trivial Names & Synonyms
Database Accession ID's
Molecular Features
Polymorphisms
Substrates and Kinetic Values
Tissue Expression & Cellular Localization
Reference List

ALDH3A2

Summary for ALDH3A2:

ALDH3A2 is a microsomal NAD+-dependent homodimer (~54.8 kDa subunits) necessary for the oxidation of long-chain aliphatic aldehydes to fatty acids (9133646) .

A heterogenous group of mutations in the ALDH3A2 gene have been identified as a causal link to Sjogren-Larsson Syndrome (SLS), an autosomal recessive disorder characterized by ichthyosis, mental retardation, spasticity, and deficient activity of ALDH3A2 (11306053) , (10577908) .

 
 

Trivial Names and Synonyms for ALDH3A2:

Ahd-3r (Ahd3-r),    Ahd3 (Ahd-3),    AI194803,    Aldehyde dehydrogenase, microsomal,    ALDH10,    Aldh4,    Aldh4-r,    DKFZp686E23276,    FALDH,    Fatty aldehyde dehydrogenase ,    FLJ20851,    SLS
 
 

Database Accession ID's for ALDH3A2:

Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Homo sapiens
(Human)
Institute Database Accession No.
NCBICCDS11210.1
NCBIEntrez Gene224
NCBIGenBankNC_000017
NCBIOMIM609523
NCBIUniGene499886
HUGOHGNC403
EBI, WTSIEnsembl - GeneViewENSG00000072210
Institute Database Accession No.
NCBIGenBankNM_001031806, NM_000382
EBI, WTSIEnsembl - TransViewENST00000339618, ENST00000404114, ENST00000176643, ENST00000395575
Institute Database Accession No.
NCBIAceViewALDH3A2.aApr07, ALDH3A2.lApr07, ALDH3A2.bApr07, ALDH3A2.eApr07
NCBIEntrez ProteinNP_001026976, NP_000373
EBI, WTSIEnsembl - ProtViewENSP00000345774, ENSP00000176643
EBI, WTSIEnsembl - TransViewENSP00000378942, ALDH3A2.cApr07, ENSP00000385699
EBI, SIB, PIRUniProtQ6I9T3, P51648
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Mus musculus
(House mouse)
Institute Database Accession No.
NCBIEntrez Gene11671
NCBIGenBankNC_000077
NCBIUniGene145091
JLMGI1353452
EBI, WTSIEnsembl - GeneViewENSMUSG00000010025
Institute Database Accession No.
NCBIGenBankNM_007437
EBI, WTSIEnsembl - TransViewENSMUST00000071413, ENSMUST00000102664, ENSMUST00000066277, ENSMUST00000074127
Institute Database Accession No.
NCBIEntrez ProteinNP_031463
EBI, WTSIEnsembl - ProtViewENSMUSP00000071361, ENSMUSP00000090711, ENSMUSP00000067767, ENSMUSP00000073764, ENSMUSP00000099725
EBI, SIB, PIRUniProtP47740, Q5SRE1
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Rattus norvegicus
(Norway rat)
Institute Database Accession No.
NCBIEntrez Gene65183
NCBIGenBankNC_005109
NCBIUniGene9113
MCWRGD61866
EBI, WTSIEnsembl - GeneViewENSRNOG00000002342
Institute Database Accession No.
NCBIGenBankNM_031731
EBI, WTSIEnsembl - TransViewENSRNOT00000038081, ENSRNOT00000003200, ENSRNOT00000040910
Institute Database Accession No.
NCBIEntrez ProteinNP_113919
EBI, WTSIEnsembl - ProtViewENSRNOP00000037740, ENSRNOP00000003200, ENSRNOP00000045886
EBI, SIB, PIRUniProtP30839
 
 
 

Molecular Features for ALDH3A2:

Species  
Homo sapiens
(Human)
Chromosome Locus : 17 p 11.2 (+ strand)
 

 
ALDH3A2_v1     (Alternative Splice Variant 1) Number of Exons for ALDH3A2_v1 :   10 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 1
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000176643 3702 ENSP00000176643 485 54848 7.99 Click Here for Graphical and Tabular Details

NM_000382 3702 NP_000373 485 54848 7.98 Click Here for Graphical and Tabular Details

ALDH3A2.bApr07 3929 ALDH3A2.bApr07 485 54848 7.98 Click Here for Graphical and Tabular Details

 
 
ALDH3A2_v2     (Alternative Splice Variant 2) Number of Exons for ALDH3A2_v2 :   11 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 2
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000339618 3823 ENSP00000345774 508 57670 9.29 Click Here for Graphical and Tabular Details

NM_001031806 3823 NP_001026976 508 57670 9.06 Click Here for Graphical and Tabular Details

ALDH3A2.aApr07 3827 ALDH3A2.aApr07 508 57670 Click Here for Graphical and Tabular Details

 
 
ALDH3A2_v3     (Alternative Splice Variant 3) Number of Exons for ALDH3A2_v3 :   11 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 3
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 3
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000395575 3627 ENSP00000378942 485 54848 7.99 Click Here for Graphical and Tabular Details

ALDH3A2.cApr07 1729 ALDH3A2.cApr07 485 54848 7.98 Click Here for Graphical and Tabular Details

 
 
ALDH3A2_v4     (Alternative Splice Variant 4) Number of Exons for ALDH3A2_v4 :   10 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 4
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 4
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000404114 1714 ENSP00000385699 508 57670 9.29 Click Here for Graphical and Tabular Details

 
 
ALDH3A2_v5     (Alternative Splice Variant 5) Number of Exons for ALDH3A2_v5 :   7 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 5
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 5
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH3A2.eApr07 2351 ALDH3A2.eApr07 292 33025 8.54 Click Here for Graphical and Tabular Details

 
 
ALDH3A2_v6     (Alternative Splice Variant 6) Number of Exons for ALDH3A2_v6 :   3 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 6
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 6
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH3A2.lApr07 1170 ALDH3A2.lApr07 97 10973 9.84 Click Here for Graphical and Tabular Details

 
Species  
Mus musculus
(House mouse)
Chromosome Locus : 11 34.3 cM (- strand)
 

 
ALDH3A2_v1     (Alternative Splice Variant 1) Number of Exons for ALDH3A2_v1 :   10 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 1
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000074127 3087 ENSMUSP00000073764 484 53971 8.51 Click Here for Graphical and Tabular Details

ENSMUST00000102664 3086 ENSMUSP00000099725 426 47683 5.58 Click Here for Graphical and Tabular Details

Deletions : 1 base deletion(s) identified

NM_007437 3131 NP_031463 484 53971 8.59 Click Here for Graphical and Tabular Details

 
 
ALDH3A2_v2     (Alternative Splice Variant 2) Number of Exons for ALDH3A2_v2 :   10 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 2
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000066277 1779 ENSMUSP00000067767 532 59277 8.24 Click Here for Graphical and Tabular Details

 
 
ALDH3A2_v3     (Alternative Splice Variant 3) Number of Exons for ALDH3A2_v3 :   10 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 3
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 3
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000071413 1704 ENSMUSP00000071361 507 56669 9.48 Click Here for Graphical and Tabular Details

 
Species  
Rattus norvegicus
(Norway rat)
Chromosome Locus : 10 q 22 (- strand)
 

 
ALDH3A2_v1     (Alternative Splice Variant 1) Number of Exons for ALDH3A2_v1 :   10 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 1
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
NM_031731 2977 NP_113919 484 54108 7.56 Click Here for Graphical and Tabular Details

 
 
ALDH3A2_v2     (Alternative Splice Variant 2) Number of Exons for ALDH3A2_v2 :   10 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 2
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000040910 1645 ENSRNOP00000045886 507 56843 8.93 Click Here for Graphical and Tabular Details

 
 
ALDH3A2_v3     (Alternative Splice Variant 3) Number of Exons for ALDH3A2_v3 :   9 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 3
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 3
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000038081 1278 ENSRNOP00000037740 425 47632 5.11 Click Here for Graphical and Tabular Details

Deletions : 4 base deletion(s) identified

 
 
ALDH3A2_v?     (Alternative Splice Variant Unknown or To Be Determined) Number of Exons : N/A Click Here for Rattus norvegicus Transcript Sequences for Unknown Variants
Click Here for Rattus norvegicus Peptide Sequences for Unknown Variants
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000003200 1573 ENSRNOP00000003200 484 54080 7.99 Click Here for Graphical and Tabular Details

Transcript : Incomplete sequence. No termination signal (TAA TGA TAG) present.

Peptide : Incomplete sequence. No stop codon present in the transcript sequence.

 
 
 

Polymorphisms for ALDH3A2:

Currently Under Development
 
 

Substrates, Inhibitors and Enzyme Kinetics for ALDH3A2:

 
 

Tissue Expression & Cellular Localization for ALDH3A2:

Currently Under Development
 
 

Reference List for ALDH3A2:

ALDH3A2 Year Authors Title Journal Pubmed ID
2007 Ashibe, Hirai, Higashi, Sekimizu, Motojima
Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing. J Biol Chem 17510064
 
2001 Rizzo, Lin, Carney
Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sjögren-Larsson syndrome. Chem Biol Interact 11306053
 
1999 Rizzo, Carney, Lin
The molecular basis of Sjögren-Larsson syndrome: mutation analysis of the fatty aldehyde dehydrogenase gene. Am J Hum Genet 10577908
 
1997 Kelson, Secor McVoy, Rizzo
Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization. Biochim Biophys Acta 9133646
 
 
 

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