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ALDH3B1

ALDH Gene Record


Summary for ALDH3B1
Trivial Names & Synonyms
Database Accession ID's
Molecular Features
Polymorphisms
Substrates and Kinetic Values
Tissue Expression & Cellular Localization
Reference List

ALDH3B1

Summary for ALDH3B1:

ALDH3B1 is a mitochondrial homodimer first cloned and sequenced by Hsu et al (7828891) .

ALDH3B1 is expressed in the kidney, lung and brain at elevated levels.

The structures of both ALDH3B1 and ALDH3B2 were reported in 1997 and suggest that from the conserved positions of the introns, gene duplication is involved in the expansion of the ALDH gene family (9161417) .

 
 

Trivial Names and Synonyms for ALDH3B1:

1700001N19Rik,    ALDH4,    ALDH7,    FLJ26433,    MGC95025
 
 

Database Accession ID's for ALDH3B1:

Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Homo sapiens
(Human)
Institute Database Accession No.
NCBIEntrez Gene221
NCBIGenBankNC_000011
NCBIOMIM600466
NCBIUniGene523841
HUGOHGNC410
EBI, WTSIEnsembl - GeneViewENSG00000006534
Institute Database Accession No.
NCBIGenBankNM_001030010, BC013584, NM_000694, AB209651, BC033099
EBI, WTSIEnsembl - TransViewENST00000342456, ENST00000316367, ENST00000007633
Institute Database Accession No.
NCBIAceViewALDH3B1.cApr07, ALDH3B1.eApr07, ALDH3B1.aApr07, ALDH3B1.dApr07, ALDH3B1.kApr07
NCBIEntrez ProteinNP_001025181, NP_000685
NCBIGenBankAAH13584, BAD92888, AAH33099
EBI, WTSIEnsembl - ProtViewENSP00000341582, ENSP00000318252, ENSP00000007633
EBI, SIB, PIRUniProtQ59F10, P43353
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Mus musculus
(House mouse)
Institute Database Accession No.
NCBIEntrez Gene67689
NCBIGenBankNC_000085
NCBIUniGene109341
JLMGI1914939
EBI, WTSIEnsembl - GeneViewENSMUSG00000024885
Institute Database Accession No.
NCBIGenBankNM_026316
EBI, WTSIEnsembl - TransViewENSMUST00000100035, ENSMUST00000051803
Institute Database Accession No.
NCBIEntrez ProteinNP_080592
EBI, WTSIEnsembl - ProtViewENSMUSP00000097612, ENSMUSP00000056276
EBI, SIB, PIRUniProtQ80VQ0
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Rattus norvegicus
(Norway rat)
Institute Database Accession No.
NCBIEntrez Gene309147
NCBIGenBankNC_005100
NCBIUniGene162510
MCWRGD1359546
EBI, WTSIEnsembl - GeneViewENSRNOG00000017872
Institute Database Accession No.
NCBIGenBankNM_001006998
EBI, WTSIEnsembl - TransViewENSRNOT00000047041, ENSRNOT00000054855
EBI, SIB, PIRUniProtENSRNOT00000023789
Institute Database Accession No.
NCBIEntrez ProteinNP_001006999
EBI, WTSIEnsembl - ProtViewENSRNOP00000023789, ENSRNOP00000051736, ENSRNOP00000043296, ENSRNOP00000024034
EBI, WTSIEnsembl - TransViewENSRNOP00000051737
EBI, SIB, PIRUniProtQ5XI42
 
 
 

Molecular Features for ALDH3B1:

Species  
Homo sapiens
(Human)
Chromosome Locus : 11 q 13 (+ strand)
 

 
ALDH3B1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH3B1_v1 :   10 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 1
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000007633 2807 ENSP00000007633 465 51599 7.67 Click Here for Graphical and Tabular Details

Transcript : When compared to the gene sequence, this transcript contains 6 deletions within the sequence. 2 deletions on Exon 3, 2 deletions on Exon 7 and 2 deletions on Exon 10. Translation of the transcript sequence derived from the gene sequence results in truncation of the amino acid sequence 4 residues following the first deletion on Exon 3. Lastly, Ensembl incorrectly records the number of exons for this transcript reporting there are 13 exons. This is incorrect as Ensembl treats these 2 base deletions as introns. There is actually only 10 Exons for this ALDH3B1 transcript.

Peptide : This peptide is derived from a transcript sequence that contains 6 deletions when compared to the gene sequence.

Deletions : 6 base deletion(s) identified

NM_000694 2857 NP_000685 468 51840 7.55 Click Here for Graphical and Tabular Details

Transcript : This transcript has 3 insertions when compared to the gene sequence (Exon 3, 7 and 9) all within the coding sequence of the protein. When compared to the gene sequence removal of the first insertion on Exon 3 would result in a truncated protein.

Peptide : Protein sequence differs from all Ensembl entries.

Insertions : 3 base insertion(s) identified

ALDH3B1.cApr07 2829 ALDH3B1.cApr07 248 27666 8.87 Click Here for Graphical and Tabular Details

BC013584 2825 AAH13584 468 51840 Click Here for Graphical and Tabular Details

Insertions : 3 base insertion(s) identified

 
 
ALDH3B1_v2     (Alternative Splice Variant 2) Number of Exons for ALDH3B1_v2 :   9 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 2
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000342456 2699 ENSP00000341582 429 47555 7.88 Click Here for Graphical and Tabular Details

Transcript : This transcript contains 4 base deletions, 2 on Exon 6 and 2 on Exon 9. Comparing this sequence to that of the gene sequence the incorporation of these deletions into the transcript sequence results in early truncation of the amino acid sequence in the following exon, Exon 7. Lastly, the number of exons for this transcript as reported by Ensembl is incorrect "13 Exons". Ensembl treats these deletions as introns. The correct number of Exons is 9.

Peptide : This protein sequence is derived from a transcript sequence that contains 4 deletions when compared to the gene sequence.

Deletions : 4 base deletion(s) identified

NM_001030010 2746 NP_001025181 431 47683 7.98 Click Here for Graphical and Tabular Details

Transcript : This transcript has 2 insertions when compared to the gene sequence on Exon 6 and 9 (positions 867 and 1344 respectively). Without the first insertion, the gene transcript results in a truncated protein.

Insertions : 2 base insertion(s) identified

ALDH3B1.aApr07 2702 ALDH3B1.aApr07 292 32645 8.99 Click Here for Graphical and Tabular Details

BC033099 2078 AAH33099 431 47683 Click Here for Graphical and Tabular Details

Insertions : 2 base insertion(s) identified

 
 
ALDH3B1_v3     (Alternative Splice Variant 3) Number of Exons for ALDH3B1_v3 :   9 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 3
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 3
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH3B1.dApr07 5879 ALDH3B1.dApr07 248 27666 8.87 Click Here for Graphical and Tabular Details

 
 
ALDH3B1_v4     (Alternative Splice Variant 4) Number of Exons for ALDH3B1_v4 :   7 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 4
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 4
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH3B1.eApr07 1408 ALDH3B1.eApr07 223 24708 8.29 Click Here for Graphical and Tabular Details

 
 
ALDH3B1_v5     (Alternative Splice Variant 5) Number of Exons for ALDH3B1_v5 :   9 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 5
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 5
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ALDH3B1.kApr07 1686 ALDH3B1.kApr07 88 9695 7.86 Click Here for Graphical and Tabular Details

 
 
ALDH3B1_v6     (Alternative Splice Variant 6) Number of Exons for ALDH3B1_v6 :   8 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 6
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 6
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
AB209651 4989 BAD92888 447 49172 Click Here for Graphical and Tabular Details

Insertions : 3 base insertion(s) identified

 
 
ALDH3B1_v?     (Alternative Splice Variant Unknown or To Be Determined) Number of Exons : N/A Click Here for Homo sapiens Transcript Sequences for Unknown Variants
Click Here for Homo sapiens Peptide Sequences for Unknown Variants
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000316367 764 ENSP00000318252 229 25327 8.95 Click Here for Graphical and Tabular Details

Transcript : This sequence is diffucult to align to the gene sequence. When aligned to the gene sequence, Exon 7 of this transcript exhibits a base deletion immediately prior to a 5' intron boundary. Otherwise this transcript cannnot be considered a valid transcript.

Peptide : Variant 2.

Deletions : 3 base deletion(s) identified

 
Species  
Mus musculus
(House mouse)
Chromosome Locus : 19 A (- strand)
 

 
ALDH3B1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH3B1_v1 :   10 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 1
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000051803 1875 ENSMUSP00000056276 468 52292 7.50 Click Here for Graphical and Tabular Details

NM_026316 1915 NP_080592 468 52292 7.5 Click Here for Graphical and Tabular Details

 
 
ALDH3B1_v2     (Alternative Splice Variant 2) Number of Exons for ALDH3B1_v2 :   3 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 2
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000100035 848 ENSMUSP00000097612 114 12753 9.82 Click Here for Graphical and Tabular Details

Transcript : This may be an incomplete segment.

Peptide : This may be an incomplete sequence.

Deletions : 1 base deletion(s) identified

 
Species  
Rattus norvegicus
(Norway rat)
Chromosome Locus : 1 q 42 (- strand)
 

 
ALDH3B1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH3B1_v1 :   10 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 1
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
NM_001006998 1913 NP_001006999 468 52147 6.68 Click Here for Graphical and Tabular Details

ENSRNOT00000023789 1863 ENSRNOP00000023789 468 52147 7.08 Click Here for Graphical and Tabular Details

 
 
ALDH3B1_v2     (Alternative Splice Variant 2) Number of Exons for ALDH3B1_v2 :   3 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 2
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000047041 312 ENSRNOP00000043296 103 11305 10.09 Click Here for Graphical and Tabular Details

 
 
ALDH3B1_v3     (Alternative Splice Variant 3) Number of Exons for ALDH3B1_v3 :   3 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 3
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 3
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000054855 444 ENSRNOP00000051737 76 8550 9.62 Click Here for Graphical and Tabular Details

Transcript : May be an incomplete sequence. Ensembl entry lacks an ATG initiation codon.

Peptide : May be an incomplete transcript sequence as the Ensembl entry lacked an ATG initialization codon.

Deletions : 4 base deletion(s) identified

 
 
 

Polymorphisms for ALDH3B1:

Currently Under Development
 
 

Substrates, Inhibitors and Enzyme Kinetics for ALDH3B1:

 
 

Tissue Expression & Cellular Localization for ALDH3B1:

Currently Under Development
 
 

Reference List for ALDH3B1:

ALDH3B1 Year Authors Title Journal Pubmed ID
2007 Marchitti, Orlicky, Vasiliou
Expression and initial characterization of human ALDH3B1. Biochem Biophys Res Commun 17382292
 
2005 Sun, Jia, Zhang, Xu, Shen, Li
Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method. Sci China C Life Sci 16092759
 
1997 Hsu, Chang, Yoshida
Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. Gene 9161417
 
1994 Hsu, Chang, Yoshida
Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. Gene 7828891
 
 
 

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