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ALDH8A1

ALDH Gene Record


Summary for ALDH8A1
Trivial Names & Synonyms
Database Accession ID's
Molecular Features
Polymorphisms
Substrates and Kinetic Values
Tissue Expression & Cellular Localization
Reference List

ALDH8A1

Summary for ALDH8A1:

ALDH8A1, a cytosolic enzyme (~53.4 kDa subunits), is considered to be a retinaldehyde dehydrogenase (RALDH4) that oxidizes retinaldehyde to retinoic acid. It plays a role in the 9-cis-retinoic acid biosynthesis pathway in vivo by converting 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid.

ALDH8A1 has approximately a 40-fold higher activity with 9-cis-retinal than with all-trans-retinal (11007799) .

ALDH8A1 is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Two transcript variants encoding distinct isoforms have been identified for this gene.

 
 

Trivial Names and Synonyms for ALDH8A1:

Aldehyde dehydrogenase 12,    ALDH12,    LOC308927 (rat),    Raldh4,    Retinal dehydrogenase type 4
 
 

Database Accession ID's for ALDH8A1:

Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Homo sapiens
(Human)
Institute Database Accession No.
NCBICCDS5172.1, 5171.1
NCBIEntrez Gene64577
NCBIGenBankNC_000006
NCBIOMIM606467
NCBIUniGene486520
HUGOHGNC15471
EBI, WTSIEnsembl - GeneViewENSG00000118514
Institute Database Accession No.
NCBIGenBankNM_022568, NM_170771
EBI, WTSIEnsembl - TransViewENST00000367845, ENST00000349305, ENST00000367847, ENST00000265605
Institute Database Accession No.
NCBIAceViewHBS1LandALDH8A1.bApr07, HBS1LandALDH8A1.dApr07, HBS1LandALDH8A1.kApr07, HBS1LandALDH8A1.aApr07, HBS1LandALDH8A1.cApr07, HBS1LandALDH8A1.fApr07
NCBIEntrez ProteinNP_072090, NP_739577
EBI, WTSIEnsembl - ProtViewENSP00000356819, ENSP00000325473, ENSP00000356821, ENSP00000265605
EBI, SIB, PIRUniProtQ9H2A2
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Mus musculus
(House mouse)
Institute Database Accession No.
NCBIEntrez Gene237320
NCBIGenBankNC_000076
NCBIUniGene90181
JLMGI2653900
EBI, WTSIEnsembl - GeneViewENSMUSG00000037542
Institute Database Accession No.
NCBIGenBankNM_178713
EBI, WTSIEnsembl - TransViewENSMUST00000042699
Institute Database Accession No.
NCBIEntrez ProteinNP_848828
EBI, WTSIEnsembl - ProtViewENSMUSP00000038878
EBI, SIB, PIRUniProtQ8BH00, Q91WS6
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Rattus norvegicus
(Norway rat)
Institute Database Accession No.
NCBIEntrez Gene308927
NCBIGenBankNC_005100
NCBIUniGene44523
MCWRGD1309347
EBI, WTSIEnsembl - GeneViewENSRNOG00000014907
Institute Database Accession No.
NCBIGenBankXM_001065122
EBI, WTSIEnsembl - TransViewENSRNOT00000020015
Institute Database Accession No.
NCBIGenBankXP_001065122
EBI, WTSIEnsembl - ProtViewENSRNOP00000020015
 
 
 

Molecular Features for ALDH8A1:

Species  
Homo sapiens
(Human)
Chromosome Locus : 6 q 23.2 (- strand)
 

 
ALDH8A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH8A1_v1 :   7 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 1
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000265605 2541 ENSP00000265605 487 53402 7.16 Click Here for Graphical and Tabular Details

ENST00000367847 2536 ENSP00000356821 487 53402 7.16 Click Here for Graphical and Tabular Details

NM_022568 2549 NP_072090 487 53402 6.76 Click Here for Graphical and Tabular Details

HBS1LandALDH8A1.dApr07 2649 HBS1LandALDH8A1.dApr07 487 53402 6.76 Click Here for Graphical and Tabular Details

 
 
ALDH8A1_v2     (Alternative Splice Variant 2) Number of Exons for ALDH8A1_v2 :   6 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 2
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000349305 2379 ENSP00000325473 433 47325 6.32 Click Here for Graphical and Tabular Details

ENST00000367845 2374 ENSP00000356819 433 47325 6.32 Click Here for Graphical and Tabular Details

NM_170771 2387 NP_739577 433 47325 5.97 Click Here for Graphical and Tabular Details

 
 
ALDH8A1_v3     (Alternative Splice Variant 3) Number of Exons for ALDH8A1_v3 :   6 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 3
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 3
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
HBS1LandALDH8A1.kApr07 2358 HBS1LandALDH8A1.kApr07 197 21673 9.14 Click Here for Graphical and Tabular Details

Transcript : This transcript does not read / overlap the vicinity of variants 1 and 2. Analysis of the translation of this sequence demonstrates no ALDH protein domain according to Pfam. Pfam does show 2 other domain matches to this translation sequence GTP_EFTU_D2 and GTP_EFTU_D3 (e-values 1.7e-13 and 4.1e-36, respectively)

 
 
ALDH8A1_v?     (Alternative Splice Variant Unknown or To Be Determined) Number of Exons : N/A Click Here for Homo sapiens Transcript Sequences for Unknown Variants
Click Here for Homo sapiens Peptide Sequences for Unknown Variants
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
HBS1LandALDH8A1.aApr07 7158 HBS1LandALDH8A1.aApr07 684 75473 6.17 Click Here for Graphical and Tabular Details

HBS1LandALDH8A1.bApr07 2794 HBS1LandALDH8A1.bApr07 632 70129 5.63 Click Here for Graphical and Tabular Details

HBS1LandALDH8A1.cApr07 2605 HBS1LandALDH8A1.cApr07 520 56962 8.61 Click Here for Graphical and Tabular Details

HBS1LandALDH8A1.fApr07 2028 HBS1LandALDH8A1.fApr07 382 41669 6.53 Click Here for Graphical and Tabular Details

 
Species  
Mus musculus
(House mouse)
Chromosome Locus : 10 3 A (+ strand)
 

 
ALDH8A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH8A1_v1 :   7 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 1
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000042699 2243 ENSMUSP00000038878 487 53664 7.60 Click Here for Graphical and Tabular Details

NM_178713 2243 NP_848828 487 53664 7.50 Click Here for Graphical and Tabular Details

 
Species  
Rattus norvegicus
(Norway rat)
Chromosome Locus : 1 p 12 (+ strand)
 

 
ALDH8A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH8A1_v1 :   8 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 1
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
XM_001065122 1408 XP_001065122 464 51095 7.50 Click Here for Graphical and Tabular Details

 
 
ALDH8A1_v2     (Alternative Splice Variant 2) Number of Exons for ALDH8A1_v2 :   7 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 2
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 2
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000020015 1464 ENSRNOP00000020015 487 53422 7.16 Click Here for Graphical and Tabular Details

 
 
 

Polymorphisms for ALDH8A1:

Currently Under Development
 
 

Substrates, Inhibitors and Enzyme Kinetics for ALDH8A1:

 
 

Tissue Expression & Cellular Localization for ALDH8A1:

Currently Under Development
 
 

Reference List for ALDH8A1:

ALDH8A1 Year Authors Title Journal Pubmed ID
2004 Marlier, Gilbert
Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Gene Expr Patterns 15567713
 
2003 Lin, Zhang, Abraham, Smith, Napoli
Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells. J Biol Chem 12519776
 
2000 Lin, Napoli
cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12. J Biol Chem 11007799
 
2000 Duester
Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur J Biochem 10880953
 
 
 

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