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ALDH9A1

ALDH Gene Record


Summary for ALDH9A1
Trivial Names & Synonyms
Database Accession ID's
Molecular Features
Polymorphisms
Substrates and Kinetic Values
Tissue Expression & Cellular Localization
Reference List

ALDH9A1

Summary for ALDH9A1:

ALDH9A1 was first purified from liver and characterized by Kurys (2925663) .

ALDH9A1 is a cytosolic tetramer (~53.8 kDa subunits) catalyzing the dehydrogenation of gamma-aminobutyraldehyde (Km = 5-14 uM) and aminoaldehydes derived from polyamines.

ALDH9A1 has also been identified as a betaine aldehyde dehydrogenase (7646513) .

ALDH9A1 is highly expressed in the liver, skeletal muscle, and kidney (2925663) , (8786138) but is undetectable in lung, placenta and brain (8786138) .

However, a variant of the liver isozyme is found in all regions of the brain with the highest levels present in the spinal cord (8645224) .

 
 

Trivial Names and Synonyms for ALDH9A1:

4-trimethylaminobutyraldehyde dehydrogenase,    AA139417,    Aldehyde dehydrogenase E3 isozyme,    ALDH4,    ALDH7,    ALDH9,    Betaine Aldehyde Dehydrogenase,    ESTM40,    Gamma-aminobutyraldehyde dehydrogenase,    MGI:1335195,    MGI:1861622,    TMABADH (TMABA-DH)
 
 

Database Accession ID's for ALDH9A1:

Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Bos taurus
(Domestic cow)
Institute Database Accession No.
NCBIEntrez Gene537539
NCBIUniGene16137
Institute Database Accession No.
NCBIGenBankNM_001046423
Institute Database Accession No.
NCBIEntrez ProteinNP_001039888
EBI, SIB, PIRUniProtQ2KJH9
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Homo sapiens
(Human)
Institute Database Accession No.
NCBICCDS1250.1
NCBIEntrez Gene223
NCBIGenBankNC_000001
NCBIOMIM602733
NCBIUniGene2533
HUGOHGNC412
EBI, WTSIEnsembl - GeneViewENSG00000143149
Institute Database Accession No.
NCBIGenBankNM_000696
EBI, WTSIEnsembl - TransViewENST00000354775, ENST00000271359
Institute Database Accession No.
NCBIAceViewALDH9A1.aApr07
NCBIEntrez ProteinNP_000687
EBI, WTSIEnsembl - ProtViewENSP00000346827, ENSP00000271359
EBI, SIB, PIRUniProtP49189, Q6NSM2
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Mus musculus
(House mouse)
Institute Database Accession No.
NCBIEntrez Gene56752
NCBIGenBankNC_000067
NCBIUniGene330055, 393238
JLMGI1335195
EBI, WTSIEnsembl - GeneViewENSMUSG00000026687
Institute Database Accession No.
NCBIGenBankNM_019993
EBI, WTSIEnsembl - TransViewENSMUST00000028004
Institute Database Accession No.
NCBIEntrez ProteinNP_064377
EBI, WTSIEnsembl - ProtViewENSMUSP00000028004
EBI, SIB, PIRUniProtQ9JLJ2
 
Species Gene-related Accession ID's Transcript-related Accession ID's Protein-related Accession ID's
Rattus norvegicus
(Norway rat)
Institute Database Accession No.
NCBIEntrez Gene64040
NCBIGenBankNC_005112
NCBIUniGene98155
MCWRGD68409
EBI, WTSIEnsembl - GeneViewENSRNOG00000004027
Institute Database Accession No.
NCBIGenBankNM_022273
EBI, WTSIEnsembl - TransViewENSRNOT00000005611
Institute Database Accession No.
NCBIEntrez ProteinNP_071609
EBI, WTSIEnsembl - ProtViewENSRNOP00000005611
EBI, SIB, PIRUniProtQ9JLJ3
 
 
 

Molecular Features for ALDH9A1:

Species  
Bos taurus
(Domestic cow)
Chromosome Locus : 3 (+ strand)
 
ALDH9A1_v?     (Alternative Splice Variant Unknown or To Be Determined) Number of Exons : N/A Click Here for Bos taurus Transcript Sequences for Unknown Variants
Click Here for Bos taurus Peptide Sequences for Unknown Variants
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
NM_001046423 0 NP_001039888 494 53976 5.84 Click Here for Graphical and Tabular Details

Transcript :

 
Species  
Homo sapiens
(Human)
Chromosome Locus : 1 q 23.1 (- strand)
 

 
ALDH9A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH9A1_v1 :   11 Click Here for Homo sapiens Transcript Sequences for Alternative Splice Variant 1
Click Here for Homo sapiens Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENST00000271359 2004 ENSP00000271359 494 53802 5.61 Click Here for Graphical and Tabular Details

ENST00000354775 2500 ENSP00000346827 518 56292 6.51 Click Here for Graphical and Tabular Details

NM_000696 2500 NP_000687 518 56292 6.23 Click Here for Graphical and Tabular Details

ALDH9A1.aApr07 2700 ALDH9A1.aApr07 518 56292 6.23 Click Here for Graphical and Tabular Details

 
Species  
Mus musculus
(House mouse)
Chromosome Locus : 1 2 H (+ strand)
 

 
ALDH9A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH9A1_v1 :   11 Click Here for Mus musculus Transcript Sequences for Alternative Splice Variant 1
Click Here for Mus musculus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSMUST00000028004 2364 ENSMUSP00000028004 518 55888 7.50 Click Here for Graphical and Tabular Details

 
 
ALDH9A1_v?     (Alternative Splice Variant Unknown or To Be Determined) Number of Exons : N/A Click Here for Mus musculus Transcript Sequences for Unknown Variants
Click Here for Mus musculus Peptide Sequences for Unknown Variants
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
NM_019993 2834 NP_064377 518 55888 Click Here for Graphical and Tabular Details

Transcript : The sequence for this transcript does not align to the genomic DNA (NCBI build 36 March 2008) - numerous SNPs Insertions and Deletions detected. Unfortunately NCBI considers this a RefSeq. Further review is required to determin exon structure and sequence integrity.

 
Species  
Rattus norvegicus
(Norway rat)
Chromosome Locus : 13 q 24 (+ strand)
 

 
ALDH9A1_v1     (Alternative Splice Variant 1) Number of Exons for ALDH9A1_v1 :   11 Click Here for Rattus norvegicus Transcript Sequences for Alternative Splice Variant 1
Click Here for Rattus norvegicus Peptide Sequences for Alternative Splice Variant 1
Transcript Length
(b.p.'s)
Peptide Translation Length
(a.a.'s)
M.W.
(Da)
Isoelectric Point Comments
ENSRNOT00000005611 2342 ENSRNOP00000005611 521 56469 7.21 Click Here for Graphical and Tabular Details

NM_022273 2360 NP_071609 497 54050 6.31 Click Here for Graphical and Tabular Details

 
 
 

Polymorphisms for ALDH9A1:

Currently Under Development
 
 

Substrates, Inhibitors and Enzyme Kinetics for ALDH9A1:

 
 

Tissue Expression & Cellular Localization for ALDH9A1:

Currently Under Development
 
 

Reference List for ALDH9A1:

ALDH9A1 Year Authors Title Journal Pubmed ID
1997 Izaguirre, Kikonyogo, Pietruszko
Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution. Comp Biochem Physiol B Biochem Mol Biol 9417993
 
1996 Lin, Chen, Hsu, Hsieh, Yoshida
Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression. Genomics 8786138
 
1996 Kikonyogo, Pietruszko
Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution. Biochem J 8645224
 
1995 Chern, Pietruszko
Human aldehyde dehydrogenase E3 isozyme is a betaine aldehyde dehydrogenase. Biochem Biophys Res Commun 7646513
 
1995 Testore, Colombatto, Silvagno, Bedino
Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver. Int J Biochem Cell Biol 7584606
 
1992 Lee, Cho
Purification and characterization of bovine brain gamma-aminobutyraldehyde dehydrogenase. Biochem Biophys Res Commun 1449496
 
1989 Kurys, Ambroziak, Pietruszko
Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde. J Biol Chem 2925663
 
1989 Asakura, Ikeda, Matsuda
Distribution of activity converting 4-aminobutyraldehyde to gamma-aminobutyric acid in subcellular fractions of mouse brain. J Neurochem 2911024
 
 
 

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