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ALDH Overview

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ALDH Gene Superfamily

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Publications


Reviews & Updates
ALDH 1 Family
ALDH 2 Family
ALDH 3 Family
ALDH 4 Family
ALDH 5 Family
ALDH 6 Family
ALDH 7 Family
ALDH 8 Family
ALDH 9 Family
ALDH 16 Family
ALDH 18 Family

Reviews & Updates

REVIEW Year Authors Title Journal Pubmed ID
2008 Marchitti, Brocker, Stagos, Vasiliou
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily. Expert Opin Drug Metab Toxicol 18611112
 
2007 Deitrich, Petersen, Vasiliou
Removal of acetaldehyde from the body. Novartis Found Symp 17590985
 
2007 Marchitti, Deitrich, Vasiliou
Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase Pharmacol Rev 17379813
 
2006 Fong, Cheng, Tang
Antiquitin, a relatively unexplored member in the superfamily of aldehyde dehydrogenases with diversified physiological functions. Cell Mol Life Sci 17131062
 
2006 Chen, Stamler
Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. Trends Cardiovasc Med 17055381
 
2005 Vasiliou, Nebert
Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Hum Genomics 16004729
 
2004 Vasiliou, Pappa, Estey
Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism Drug Metab Rev 15237855
 
2003 Sládek
Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact J Biochem Mol Toxicol 12616643
 
2003 Sophos, Vasiliou
Aldehyde dehydrogenase gene superfamily: the 2002 update Chem Biol Interact 12604184
 
2002 Sládek
Leukemic cell insensitivity to cyclophosphamide and other oxazaphosphorines mediated by aldehyde dehydrogenase(s) Cancer Treat Res 12481716
 
2001 Sophos, Pappa, Ziegler, Vasiliou
Aldehyde dehydrogenase gene superfamily: the 2000 update Chem Biol Interact 11306055
 
2000 Vasiliou, Pappa, Petersen
Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism Chem Biol Interact 11154732
 
2000 Vasiliou, Pappa
Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease Pharmacology 10971205
 
1999 Vasiliou, Bairoch, Tipton, Nebert
Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping Pharmacogenetics 10780262
 
1999 Sládek
Aldehyde dehydrogenase-mediated cellular relative insensitivity to the oxazaphosphorines Curr Pharm Des 10469894
 
1999 Ziegler, Vasiliou
Aldehyde dehydrogenase gene superfamily. The 1998 update Adv Exp Med Biol 10352694
 
1998 Yoshida, Rzhetsky, Hsu, Chang
Human aldehyde dehydrogenase gene family. Eur J Biochem 9490025
 

ALDH 1 Family

ALDH1A1 Year Authors Title Journal Pubmed ID
2008 Lassen, Black, Estey, Vasiliou
The role of corneal crystallins in the cellular defense mechanisms against oxidative stress. Semin Cell Dev Biol 18077195
 
2007 Lassen, Bateman, Estey, Kuszak, Nees, Piatigorsky, Duester, Day, Huang, Hines, Vasiliou
Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in aldh3a1(-/-)/aldh1a1(-/-) knockout mice. J Biol Chem 17567582
 
2003 Manzer, Qamar, Estey, Pappa, Petersen, Vasiliou
Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA DNA Cell Biol 12941160
 
2003 Fan, Molotkov, Manabe, Donmoyer, Deltour, Foglio, Cuenca, Blaner, Lipton, Duester
Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol 12808103
 
2002 Sládek, Kollander, Sreerama, Kiang
Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens Cancer Chemother Pharmacol 11914911
 
2002 Niederreither, Fraulob, Garnier, Chambon, Dollé
Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse. Mech Dev 11744377
 
2001 Pappa, Sophos, Vasiliou
Corneal and stomach expression of aldehyde dehydrogenases: from fish to mammals Chem Biol Interact 11306042
 
2000 Reichard, Vasiliou, Petersen
Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver Biochim Biophys Acta 11018474
 
2000 Duester
Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur J Biochem 10880953
 
2000 Moreb, Maccow, Schweder, Hecomovich
Expression of antisense RNA to aldehyde dehydrogenase class-1 sensitizes tumor cells to 4-hydroperoxycyclophosphamide in vitro. J Pharmacol Exp Ther 10773007
 
1999 Jester, Moller-Pedersen, Huang, Sax, Kays, Cavangh, Petroll, Piatigorsky
The cellular basis of corneal transparency: evidence for corneal crystallins. J Cell Sci 9973596
 
1999 Haselbeck, Hoffmann, Duester
Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways. Dev Genet 10570467
 
1999 Niederreither, Subbarayan, Dollé, Chambon
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet 10192400
 
1998 King, Holmes
Human ocular aldehyde dehydrogenase isozymes: distribution and properties as major soluble proteins in cornea and lens. J Exp Zool 9723161
 
1998 Piatigorsky
Gene sharing in lens and cornea: facts and implications. Prog Retin Eye Res 9695791
 
1998 Piatigorsky
Multifunctional lens crystallins and corneal enzymes. More than meets the eye. Ann N Y Acad Sci 9599288
 
1996 Stewart, Malek, Crabb
Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 8689400
 
1995 Agarwal, von Eitzen, Meier-Tackmann, Goedde
Metabolism of cyclophosphamide by aldehyde dehydrogenases. Adv Exp Med Biol 7484368
 
1994 von Eitzen, Meier-Tackmann, Agarwal, Goedde
Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes. Cancer Lett 8124665
 
1992 Yoshida, Hsu, Davé
Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase. Enzyme 1292933
 
ALDH1A2 Year Authors Title Journal Pubmed ID
2006 Ribes, Wang, Dollé, Niederreither
Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development 16368932
 
2005 Deak, Dickerson, Linney, Enterline, George, Melvin, Graham, Siegel, Hammock, Mehltretter
Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. Birth Defects Res A Clin Mol Teratol 16237707
 
2005 Kim, Lapointe, Kaygusuz, Ong, Li, van de Rijn, Brooks, Pollack
The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer. Cancer Res 16166285
 
2002 Niederreither, Fraulob, Garnier, Chambon, Dollé
Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse. Mech Dev 11744377
 
2000 Duester
Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur J Biochem 10880953
 
1999 Haselbeck, Hoffmann, Duester
Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways. Dev Genet 10570467
 
1999 Niederreither, Subbarayan, Dollé, Chambon
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet 10192400
 
ALDH1A3 Year Authors Title Journal Pubmed ID
2007 Trasino, Harrison, Wang
Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP. Exp Biol Med (Maywood) 17526768
 
2003 Dupé, Matt, Garnier, Chambon, Mark, Ghyselinck
A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc Natl Acad Sci U S A 14623956
 
2002 Niederreither, Fraulob, Garnier, Chambon, Dollé
Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse. Mech Dev 11744377
 
2001 Pappas, Stephanou, Karamanakos, Vasiliou, Marselos
Phenobarbital inducibility and differences in protein expression of an animal model Chem Biol Interact 11306051
 
2000 Duester
Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur J Biochem 10880953
 
1999 Niederreither, Subbarayan, Dollé, Chambon
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet 10192400
 
1994 Hsu, Chang, Hiraoka, Hsieh
Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6. Genomics 7698756
 
ALDH1A7 Year Authors Title Journal Pubmed ID
ALDH1B1 Year Authors Title Journal Pubmed ID
1996 Stewart, Malek, Crabb
Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 8689400
 
1995 Stewart, Malek, Xiao, Dipple, Crabb
The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. Biochem Biophys Res Commun 7779080
 
1993 Algar, Cheung, Hayes, Holmes, Beacham
Bovine corneal aldehyde dehydrogenases: evidence for multiple gene products (ALDH3 and ALDHX). Adv Exp Med Biol 8493893
 
1991 Hsu, Chang
Cloning and characterization of a new functional human aldehyde dehydrogenase gene. J Biol Chem 2061311
 
ALDH1L1 Year Authors Title Journal Pubmed ID
2007 Anthony, Heintz
The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects. J Comp Neurol 17111379
 
2006 Anguera, Field, Perry, Ghandour, Chiang, Selhub, Shane, Stover
Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J Biol Chem 16627483
 
2003 Oleinik, Krupenko
Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in A549 cells induces G1 cell cycle arrest and apoptosis. Mol Cancer Res 12805405
 
2002 Krupenko, Oleinik
10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells. Cell Growth Differ 12065246
 
1996 Kim, Huang, Schirch, Schirch
Properties of tetrahydropteroylpentaglutamate bound to 10-formyltetrahydrofolate dehydrogenase. Biochemistry 8961940
 
1995 Wagner, Briggs, Horne, Cook
10-Formyltetrahydrofolate dehydrogenase: identification of the natural folate ligand, covalent labeling, and partial tryptic digestion. Arch Biochem Biophys 7840609
 
1993 Kuhar, Feng, Vidan, Ross, Hatten, Heintz
Changing patterns of gene expression define four stages of cerebellar granule neuron differentiation. Development 8223263
 
1988 Min, Shane, Stokstad
Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate binding protein in liver cytosol. Biochim Biophys Acta 3196754
 
1976 Krebs, Hems, Tyler
The regulation of folate and methionine metabolism. Biochem J 985432
 
1968 Kutzbach, Stokstad
Partial purification of a 10-formyl-tetrahydrofolate: NADP oxidoreductase from mammalian liver. Biochem Biophys Res Commun 4384443
 
ALDH1L2 Year Authors Title Journal Pubmed ID

ALDH 2 Family

ALDH2 Year Authors Title Journal Pubmed ID
2006 Chen, Stamler
Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. Trends Cardiovasc Med 17055381
 
2005 Lassen, Estey, Tanguay, Pappa, Reimers, Vasiliou
Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2 Drug Metab Dispos 15703303
 
2003 DiFabio, Yanbin, Vasiliou, Thatcher, Bennett
Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance Mol Pharmacol 14573760
 
2002 Luczak, Elvine-Kreis, Shea, Carr, Wall
Genetic risk for alcoholism relates to level of response to alcohol in Asian-American men and women. J Stud Alcohol 11925062
 
2001 Pappa, Sophos, Vasiliou
Corneal and stomach expression of aldehyde dehydrogenases: from fish to mammals Chem Biol Interact 11306042
 
1999 Wall, Johnson, Horn, Carr, Smith, Schuckit
Evaluation of the self-rating of the effects of alcohol form in Asian Americans with aldehyde dehydrogenase polymorphisms. J Stud Alcohol 10606490
 
1996 Stewart, Malek, Crabb
Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 8689400
 
1995 Higuchi, Matsushita, Murayama, Takagi, Hayashida
Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. Am J Psychiatry 7625477
 
1994 Farrés, Wang, Takahashi, Cunningham, Wang, Weiner
Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem 7910607
 

ALDH 3 Family

ALDH3A1 Year Authors Title Journal Pubmed ID
2008 Lassen, Black, Estey, Vasiliou
The role of corneal crystallins in the cellular defense mechanisms against oxidative stress. Semin Cell Dev Biol 18077195
 
2007 Lassen, Bateman, Estey, Kuszak, Nees, Piatigorsky, Duester, Day, Huang, Hines, Vasiliou
Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in aldh3a1(-/-)/aldh1a1(-/-) knockout mice. J Biol Chem 17567582
 
2007 Estey, Cantore, Weston, Carpenter, Petrash, Vasiliou
Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1 J Biol Chem 17158879
 
2007 Estey, Piatigorsky, Lassen, Vasiliou
ALDH3A1: a corneal crystallin with diverse functions Exp Eye Res 16797007
 
2006 Lassen, Pappa, Black, Jester, Day, Min, Min, Vasiliou
Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts Free Radic Biol Med 17023273
 
2006 Muzio, Trombetta, Maggiora, Martinasso, Vasiliou, Lassen, Canuto
Arachidonic acid suppresses growth of human lung tumor A549 cells through down-regulation of ALDH3A1 expression Free Radic Biol Med 16716894
 
2005 Pappa, Brown, Koutalos, DeGregori, White, Vasiliou
Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells J Biol Chem 15905174
 
2003 Pappa, Estey, Manzer, Brown, Vasiliou
Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in the cornea Biochem J 12943535
 
2003 Pappa, Chen, Koutalos, Townsend, Vasiliou
Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage Free Radic Biol Med 12706498
 
2003 Sládek
Transient induction of increased aldehyde dehydrogenase 3A1 levels in cultured human breast (adeno)carcinoma cell lines via 5'-upstream xenobiotic, and electrophile, responsive elements is, respectively, estrogen receptor-dependent and -independent Chem Biol Interact 12604190
 
2003 Manzer, Pappa, Estey, Sládek, Carpenter, Vasiliou
Ultraviolet radiation decreases expression and induces aggregation of corneal ALDH3A1 Chem Biol Interact 12604188
 
2002 Sládek, Kollander, Sreerama, Kiang
Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens Cancer Chemother Pharmacol 11914911
 
2001 Sládek, Rekha, Lee, Nagasawa
Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues Chem Biol Interact 11672702
 
2001 Sreerama, Sládek
Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes Chem Biol Interact 11306049
 
2001 Pappa, Sophos, Vasiliou
Corneal and stomach expression of aldehyde dehydrogenases: from fish to mammals Chem Biol Interact 11306042
 
1999 Vasiliou, Reuter, Williams, Puga, Nebert
Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression Pharmacogenetics 10591537
 
1999 Shiao, Tran, Siegel, Lee, Vasiliou
Four amino acid changes are associated with the Aldh3a1 locus polymorphism in mice which may be responsible for corneal sensitivity to ultraviolet light Pharmacogenetics 10376761
 
1999 Vasiliou, Shiao
The lack of AHD4 induction by TCDD in corneal cells may involve tissue-specific regulatory proteins Adv Exp Med Biol 10352684
 
1999 Stephanou, Pappas, Vasiliou, Marselos
Prepubertal regulation of the rat dioxin-inducible aldehyde dehydrogenase (ALDH3) Adv Exp Med Biol 10352679
 
1998 King, Holmes
Human ocular aldehyde dehydrogenase isozymes: distribution and properties as major soluble proteins in cornea and lens. J Exp Zool 9723161
 
1998 Piatigorsky
Multifunctional lens crystallins and corneal enzymes. More than meets the eye. Ann N Y Acad Sci 9599288
 
1997 Downes, Swann, Holmes
A genetic basis for corneal sensitivity to ultraviolet light among recombinant SWXJ inbred strains of mice. Curr Eye Res 9192162
 
1996 Uma, Hariharan, Sharma, Balasubramanian
Effect of UVB radiation on corneal aldehyde dehydrogenase. Curr Eye Res 8670773
 
1996 Boesch, Lee, Lindahl
Constitutive expression of class 3 aldehyde dehydrogenase in cultured rat corneal epithelium. J Biol Chem 8617795
 
1995 Agarwal, von Eitzen, Meier-Tackmann, Goedde
Metabolism of cyclophosphamide by aldehyde dehydrogenases. Adv Exp Med Biol 7484368
 
1994 Downes, Swann, Holmes
Differential corneal sensitivity to ultraviolet light among inbred strains of mice. Correlation of ultraviolet B sensitivity with aldehyde dehydrogenase deficiency. Cornea 8131409
 
1994 von Eitzen, Meier-Tackmann, Agarwal, Goedde
Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes. Cancer Lett 8124665
 
1993 Downes, Swann, Holmes
Ultraviolet light-induced pathology in the eye: associated changes in ocular aldehyde dehydrogenase and alcohol dehydrogenase activities. Cornea 8500338
 
1993 Algar, Cheung, Hayes, Holmes, Beacham
Bovine corneal aldehyde dehydrogenases: evidence for multiple gene products (ALDH3 and ALDHX). Adv Exp Med Biol 8493893
 
1993 King, Holmes
Human corneal aldehyde dehydrogenase: purification, kinetic characterisation and phenotypic variation. Biochem Mol Biol Int 8260946
 
1992 Konishi, Mimura
Kinetic properties of the bovine corneal aldehyde dehydrogenase (BCP 54). Exp Eye Res 1483503
 
1991 Algar, Abedinia, VandeBerg, Holmes
Purification and properties of baboon corneal aldehyde dehydrogenase: proposed UVR protective role. Adv Exp Med Biol 2053490
 
1990 Abedinia, Pain, Algar, Holmes
Bovine corneal aldehyde dehydrogenase: the major soluble corneal protein with a possible dual protective role for the eye. Exp Eye Res 2209753
 
1989 Evces, Lindahl
Characterization of rat cornea aldehyde dehydrogenase. Arch Biochem Biophys 2802624
 
1985 Santisteban, Povey, West, Parrington, Hopkinson
Chromosome assignment, biochemical and immunological studies on a human aldehyde dehydrogenase, ALDH3. Ann Hum Genet 4073832
 
ALDH3A2 Year Authors Title Journal Pubmed ID
2007 Ashibe, Hirai, Higashi, Sekimizu, Motojima
Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing. J Biol Chem 17510064
 
2001 Rizzo, Lin, Carney
Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sjögren-Larsson syndrome. Chem Biol Interact 11306053
 
1999 Rizzo, Carney, Lin
The molecular basis of Sjögren-Larsson syndrome: mutation analysis of the fatty aldehyde dehydrogenase gene. Am J Hum Genet 10577908
 
1997 Kelson, Secor McVoy, Rizzo
Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization. Biochim Biophys Acta 9133646
 
ALDH3B1 Year Authors Title Journal Pubmed ID
2007 Marchitti, Orlicky, Vasiliou
Expression and initial characterization of human ALDH3B1. Biochem Biophys Res Commun 17382292
 
2005 Sun, Jia, Zhang, Xu, Shen, Li
Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method. Sci China C Life Sci 16092759
 
1997 Hsu, Chang, Yoshida
Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. Gene 9161417
 
1994 Hsu, Chang, Yoshida
Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. Gene 7828891
 
ALDH3B2 Year Authors Title Journal Pubmed ID
1997 Hsu, Chang, Yoshida
Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. Gene 9161417
 
1996 Hsu, Chang
Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family. Gene 8890755
 

ALDH 4 Family

ALDH4A1 Year Authors Title Journal Pubmed ID
2004 Yoon, Nakamura, Arakawa
Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. J Hum Genet 14986171
 
1998 Geraghty, Vaughn, Nicholson, Lin, Jimenez-Sanchez, Obie, Flynn, Valle, Hu
Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia. Hum Mol Genet 9700195
 
1996 Hu, Lin, Valle
Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase. J Biol Chem 8621661
 

ALDH 5 Family

ALDH5A1 Year Authors Title Journal Pubmed ID
2007 Knerr, Pearl, Bottiglieri, Snead, Jakobs, Gibson
Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (gamma-hydroxybutyric aciduria). Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- mice and characterization of gamma-hydroxybutyric acid pharmacology. J Inherit Metab Dis 17457693
 
2003 Gupta, Hogema, Grompe, Bottiglieri, Concas, Biggio, Sogliano, Rigamonti, Pearl, Snead, et al.
Murine succinate semialdehyde dehydrogenase deficiency. Ann Neurol 12891658
 
2001 Hogema, Gupta, Senephansiri, Burlingame, Taylor, Jakobs, Schutgens, Froestl, Snead, Diaz-Arrastia, et al.
Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. Nat Genet 11544478
 
1997 Gibson, Christensen, Jakobs, Fowler, Clarke, Hammersen, Raab, Kobori, Moosa, Vollmer, et al.
The clinical phenotype of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria): case reports of 23 new patients. Pediatrics 9093300
 

ALDH 6 Family

ALDH6A1 Year Authors Title Journal Pubmed ID
2000 Kedishvili, Goodwin, Popov, Harris
Mammalian methylmalonate-semialdehyde dehydrogenase. Methods Enzymol 10989432
 
2000 Chambliss, Gray, Rylance, Pollitt, Gibson
Molecular characterization of methylmalonate semialdehyde dehydrogenase deficiency. J Inherit Metab Dis 10947204
 
1992 Kedishvili, Popov, Rougraff, Zhao, Crabb, Harris
CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distribution. J Biol Chem 1527093
 

ALDH 7 Family

ALDH7A1 Year Authors Title Journal Pubmed ID
2006 Fong, Cheng, Tang
Antiquitin, a relatively unexplored member in the superfamily of aldehyde dehydrogenases with diversified physiological functions. Cell Mol Life Sci 17131062
 
2002 Tang, Cheng, Fong
First purification of the antiquitin protein and demonstration of its enzymatic activity. FEBS Lett 11959129
 
1994 Lee, Kuhl, Gelbart, Kamimura, West, Beutler
Homology between a human protein and a protein of the green garden pea. Genomics 8088832
 

ALDH 8 Family

ALDH8A1 Year Authors Title Journal Pubmed ID
2004 Marlier, Gilbert
Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Gene Expr Patterns 15567713
 
2003 Lin, Zhang, Abraham, Smith, Napoli
Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells. J Biol Chem 12519776
 
2000 Lin, Napoli
cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12. J Biol Chem 11007799
 
2000 Duester
Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur J Biochem 10880953
 

ALDH 9 Family

ALDH9A1 Year Authors Title Journal Pubmed ID
1997 Izaguirre, Kikonyogo, Pietruszko
Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution. Comp Biochem Physiol B Biochem Mol Biol 9417993
 
1996 Lin, Chen, Hsu, Hsieh, Yoshida
Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression. Genomics 8786138
 
1996 Kikonyogo, Pietruszko
Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution. Biochem J 8645224
 
1995 Chern, Pietruszko
Human aldehyde dehydrogenase E3 isozyme is a betaine aldehyde dehydrogenase. Biochem Biophys Res Commun 7646513
 
1995 Testore, Colombatto, Silvagno, Bedino
Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver. Int J Biochem Cell Biol 7584606
 
1992 Lee, Cho
Purification and characterization of bovine brain gamma-aminobutyraldehyde dehydrogenase. Biochem Biophys Res Commun 1449496
 
1989 Kurys, Ambroziak, Pietruszko
Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde. J Biol Chem 2925663
 
1989 Asakura, Ikeda, Matsuda
Distribution of activity converting 4-aminobutyraldehyde to gamma-aminobutyric acid in subcellular fractions of mouse brain. J Neurochem 2911024
 

ALDH 16 Family

ALDH16A1 Year Authors Title Journal Pubmed ID

ALDH 18 Family

ALDH18A1 Year Authors Title Journal Pubmed ID
2000 Baumgartner, Hu, Almashanu, Steel, Obie, Aral, Rabier, Kamoun, Saudubray, Valle
Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase. Hum Mol Genet 11092761
 
1999 Hu, Lin, Obie, Valle
Molecular enzymology of mammalian Delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition. J Biol Chem 10037775
 
1980 Smith, Downing, Phang, Lodato, Aoki
Pyrroline-5-carboxylate synthase activity in mammalian cells. Proc Natl Acad Sci U S A 6933554
 

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